MPV (Monkeypox) Treatment

MPV Treatment

hand with MPV lesionsMany people with MPV get better without any treatment, but some patients benefit from either supportive care to control discomfort such as pain or itching or through treatment with a medication called tecovirimat.  

Ways to make yourself more comfortable if you have MPV: 

  • Drink plenty of water and other clear fluids to prevent dehydration.
  • Keep sores clean and dry when not showering or bathing to prevent bacterial infections.
  • Manage itching with over-the-counter oral antihistamines (such as diphenhydramine/Benadryl, cetirizine or hydroxyzine) or topical ointments such as calamine lotion or petroleum jelly (Vaseline).
  • If you are having pain in the mouth, genital region, or anus, nausea/vomiting, diarrhea, or difficulty urinating or defecating, discuss treatment options with a healthcare provider.
  • Providers may prescribe different medications depending on your symptoms:
  • Mouth pain or sores: “Magic or miracle mouthwash” or antiseptic oral rinses to decrease mouth pain and keep sores clean. Topical over-the-counter oral gels to reduce pain, such as Orajel, can be used in limited doses but should be discussed with a healthcare provider.
  • Painful sores in the genital and anal regions: warm sitz baths . Topical pain-relief gels or creams (e.g. RectiCare) may also provide temporary relief. Please note: if you have blood in your urine, difficulty urinating, inability to retract your foreskin, or your foreskin can’t return to a normal position after being retracted, contact a healthcare provider immediately. 
  • Proctitis (swelling and inflammation of the lining of the rectum internal to the anus): stool softeners such as docusate and warm sitz baths. Over the counter pain medications such as acetaminophen can also be used. Additional prescription pain medications might also be necessary, but side effects should be discussed with a healthcare provider. Please note: if you are unable to pass a bowel movement or have blood in your stool, contact a healthcare provider immediately.
  • Nausea/vomiting: prescription medications to control nausea.
  • Diarrhea: fluid and electrolyte replacement. Over-the-counter medications are not recommended. 
  • Bacterial infections: antibiotics as needed.
  • If your symptoms cannot be managed at home, reach out to your primary care physician or the clinician who diagnosed you to discuss options including tecovirimat (TPoxx).
  • MPV can occur at the same time as other sexually transmitted infections such as gonorrhea, syphilis, chlamydia, and HIV, so your healthcare provider may also evaluate and treat you for other infections.

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