MPV (Monkeypox) Vaccine & Treatment


Two vaccines are currently licensed by the U.S. Food and Drug Administration (FDA) to prevent MPV (Monkeypox) infection. In Chicago, we currently have a limited supply of JYNNEOS™ (vaccine FAQ:  English | Spanish), although we expect that vaccine availability will continue to increase in the coming weeks and months. While supply is limited, the current focus is to administer vaccine to those at the highest risk of being exposed to meaningfully interrupt chains of transmission and mitigate MPV spread. 

JYNNEOS vaccine is a two-dose vaccine given under the skin 28 days apart. Currently, first doses are being prioritized.

MPV vaccine eligibility infographic

Vaccine Eligibility

Eligibility for MPV vaccination may change over time, but currently close contacts of someone with MPV are prioritized for vaccination.

In addition, people who meet all the following conditions are eligible for vaccination:

  • Gay, bisexual, and other (cis or trans) men who have sex with men (MSM).
  • Age 18 or older.
  • Had multiple or anonymous sex partners, sex at a social or sexual venue, or sex in exchange for money or goods within the last 14 days. 

If you have had MPV, then you likely have protection against another infection and are not eligible to be vaccinated.

The vaccine is not currently recommended for the general public, including (cis or trans) men who have sex with men without the additional criteria.

How to get vaccinated

In Chicago, we have distributed vaccine to healthcare providers (e.g. Sexual health clinics, MSM- HIV-PrEP providers) who directly reach out to eligible populations.

If you think you might qualify to receive vaccine, first contact your healthcare provider. Encourage your healthcare provider to visit if they are unfamiliar with MPV. Second, please be patient. There is not currently enough vaccine for all those who qualify to receive a dose, but we will expand where vaccine is available as we receive additional doses.

The below Chicago healthcare providers have received doses of vaccine for those who meet eligibility criteria ; however, inclusion on this list does not mean that the providers have currently available doses or appointments . As supply of vaccine increases, these providers may receive additional doses and additional providers will be added to the list.

Chicago Department of Public Health: PEP Partners

Center How to schedule
CDPH Lakeview Clinic

Ask your provider for referral code

CDPH Austin Clinic
CDPH Roseland
Howard Brown Health Clark 773-388-1600   
Howard Brown Health Sheridan
Howard Brown Health 63rd
Howard Brown Health 55th
Wellness Home-Lakeview 773-296-2400
Wellness Home-Halsted 773-621-7725
RMR Core Center 312-572-4500
Rush University 888-352-7874
Project Wish/ UIC UIC MPX (Monkeypox) Outreach Sign-Up Form
UI Health Eye and Ear Infirmary
Alivio Medical Center
The University of Chicago Medical Center

Vaccine Second Doses

The full course of vaccine consists of 2 doses given at least 4 weeks apart. In Chicago, we are prioritizing giving first doses of JYNNEOS™ vaccine over supplying second doses to protect as many people as possible while the vaccine supply is low. 

People who received the first dose should receive the second dose at least 4 weeks after the first. Immunity starts to build in the days and weeks after the first dose, although full immunity does not occur until 2 weeks after the second dose. Second doses will continue to be provided for those who are known contacts of cases or who are immunocompromised; second doses will be scheduled for all others when the city receives adequate vaccine supply.

Chicago Star Chicago Star Chicago Star Chicago Star


Many people with MPV get better without any treatment, but some patients benefit from either supportive care to control discomfort such as pain or itching or through treatment with a medication called tecovirimat.  

Ways to make yourself more comfortable if you have MPV: 

  • Drink plenty of water and other clear fluids to prevent dehydration.
  • Keep sores clean and dry when not showering or bathing to prevent bacterial infections.
  • Manage itching with over-the-counter oral antihistamines (such as diphenhydramine/Benadryl, cetirizine or hydroxyzine) or topical ointments such as calamine lotion or petroleum jelly (Vaseline).
  • If you are having pain in the mouth, genital region, or anus, nausea/vomiting, diarrhea, or difficulty urinating or defecating, discuss treatment options with a healthcare provider.
  • Providers may prescribe different medications depending on your symptoms:
  • Mouth pain or sores: “Magic or miracle mouthwash” or antiseptic oral rinses to decrease mouth pain and keep sores clean. Topical over-the-counter oral gels to reduce pain, such as Orajel, can be used in limited doses but should be discussed with a healthcare provider.
  • Painful sores in the genital and anal regions: warm sitz baths . Topical pain-relief gels or creams (e.g. RectiCare) may also provide temporary relief. Please note: if you have blood in your urine, difficulty urinating, inability to retract your foreskin, or your foreskin can’t return to a normal position after being retracted, contact a healthcare provider immediately. 
  • Proctitis (swelling and inflammation of the lining of the rectum internal to the anus): stool softeners such as docusate and warm sitz baths. Over the counter pain medications such as acetaminophen can also be used. Additional prescription pain medications might also be necessary, but side effects should be discussed with a healthcare provider. Please note: if you are unable to pass a bowel movement or have blood in your stool, contact a healthcare provider immediately.
  • Nausea/vomiting: prescription medications to control nausea.
  • Diarrhea: fluid and electrolyte replacement. Over-the-counter medications are not recommended. 
  • Bacterial infections: antibiotics as needed.
  • If your symptoms cannot be managed at home, reach out to your primary care physician or the clinician who diagnosed you to discuss options including tecovirimat (TPoxx).
  • MPV can occur at the same time as other sexually transmitted infections such as gonorrhea, syphilis, chlamydia, and HIV, so your healthcare provider may also evaluate and treat you for other infections.

Chicago Star Chicago Star Chicago Star Chicago Star