MPV Vaccine

Weekend MPV Vaccination Clinics 

Appointments are available this weekend at:

  • 24-Hour Monkeypox Vax-A-Thon:
    • Location: Instituto Del Progreso Latino, 2520 S. Western Ave., Chicago
    • Schedule: Friday, September 9 at 5 p.m. through Saturday, September 10 at 5 p.m.
    • Registration: On-site registration only


Eligibility for the MPV vaccine has expanded and it is available at healthcare providers and clinics throughout the city, and CDPH strongly encourages those eligible to get the shot to protect themselves and others. Recent approval of intradermal administration (between layers of the skin) for individuals 18 years of age and older of JYNNEOS™ (vaccine FAQ:  EnglishSpanishMPV vaccine means that all eligible Chicagoans can receive the two-dose series, as recommended. In addition, Emergency Use Authorization from the FDA allows those under the age of 18 to receive the vaccine beneath the skin (subcutaneously), with the consent of their parents or guardians.

JYNNEOS™ vaccine is a two-dose vaccine given under the skin 28 days apart.

Link - CDPH MPV Advisory 9/28/2022

Vaccine Eligibility

Anyone living in Chicago and Illinois, including students enrolled in Chicago’s universities/colleges, who meet one of the following criteria AND have not previously been infected with MPV, is recommended to complete the two-dose series of MPV JYNNEOS vaccine as recommended:

  • Anyone regardless of sex, gender, or sexual orientation who:
    • Had skin-to-skin or intimate contact (e.g., household members with close physical contact or intimate partners) with someone diagnosed with MPV.

    • Exchanges good or services for sex.

    • Lives with HIV, especially persons with uncontrolled or advanced HIV disease.

    • Are eligible or currently taking PrEP (pre-exposure prophylaxis) to help prevent infection with HIV.

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  • Sexually active bisexual, gay and other same gender-loving men, or sexually active transgender individuals. Especially consider getting vaccinated if you:
    • Met recent partners through online applications or social media platforms (such as Grindr, Tinder or Scruff), or at clubs, raves, sex parties, saunas.

    • Were diagnosed with sexually transmitted infection(s) (STI) in past 6 months.

We are still learning about how well the vaccine can protect you. Even after getting vaccinated, you should still take precautions, especially if you are at high-risk for severe illness from monkeypox.

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How to get vaccinated

In Chicago, we have distributed vaccine to healthcare providers (e.g. sexual health clinics, MSM- HIV-PrEP providers) who directly reach out to eligible populations.

If you think you might qualify to receive vaccine, contact your healthcare provider or see the list of vaccine providers below. Encourage your healthcare provider to visit if they are unfamiliar with MPV. The Chicago healthcare providers listed below have received doses of vaccine for those who meet eligibility criteria. Please contact the providers directly to see if they have currently available doses or appointments. As we continue to receive vaccine, additional providers may be added to the list.

Chicago Department of Public Health: PEP Partners

Center How to schedule
CDPH Lakeview Clinic 
CDPH Austin Clinic 
CDPH Roseland 
Howard Brown Health Clark 773-388-1600   
Howard Brown Health Sheridan
Howard Brown Health 63rd
Howard Brown Health 55th
Wellness Home-Lakeview 773-296-2400
Wellness Home-Halsted 773-621-7725
RMR Core Center 312-572-4500
Rush University 888-352-7874


Esperanza MPV site

Project Wish/ UIC UIC MPX (Monkeypox) Outreach Sign-Up Form
UI Health Eye and Ear Infirmary
Alivio Medical Center
Center on Halsted - North Side
Center on Halsted - South Side/Woodlawn
Lawndale Christian Health Center
(Ogden Ave)

Vaccine Second Doses

The full course of vaccine consists of 2 doses given at least 4 weeks apart. People who received the first dose should receive the second dose at least 4 weeks after the first. Immunity starts to build in the days and weeks after the first dose, although full immunity does not occur until 2 weeks after the second dose. Anyone who has had a first dose at least 28 days ago and who has not been infected with monkeypox virus (MPV) is eligible for a second dose at this time.

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